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GSK 1059615

Cat. No. 4026 Submit a Review Datasheet / COA / SDS

Discontinued Product

4026 has been discontinued.

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Description: Potent PI 3-kinase inhibitor
Chemical Name: 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Datasheets References

Biological Activity for GSK 1059615

GSK 1059615 is a potent inhibitor of PI 3-kinase α (PI3Kα) (IC50 = 2 nM). Inhibits proliferation in BT474 cells and attenuates MAPK signaling.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for GSK 1059615

M. Wt 333.36
Formula C18H11N3O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 958852-01-2
PubChem ID 23582824
InChI Key QDITZBLZQQZVEE-YBEGLDIGSA-N
Smiles O=C(/C(S4)=C/C1=CC=C2C(C(C3=CC=NC=C3)=CC=N2)=C1)NC4=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for GSK 1059615

References are publications that support the biological activity of the product.

Saadia et al (2009) Phosphatidylinositol-3-kinase as a therapeutic target in melanoma. Clin.Cancer Res. 15 3029 PMID: 19383818

Knight et al (2010) Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of rapamycin. ACS Med.Chem.Lett. 1 39

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Citations for GSK 1059615

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