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GSK 143

Cat. No. 6362 Submit a Review Datasheet / COA / SDS
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Description: Syk inhibitor
Chemical Name: 2-[[(3R,4R)-3-Aminotetrahydro-2H-pyran-4-yl]amino]-4-[(4-methylphenyl)amino]-5-pyrimidinecarboxamide dihydrochloride
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for GSK 143

GSK 143 is a spleen tyrosine kinase (Syk) inhibitor (pIC50 = 7.5). Also inhibits phosphorylated Erk (pIC50 = 7.1). Decreases cell number and viability in chronic lymphocytic leukemia (CCL) cell lines.

Compound Libraries for GSK 143

GSK 143 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for GSK 143

M. Wt 415.32
Formula C17H22N6O2.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2341796-81-2
PubChem ID 46865656
InChI Key InChIKey=UEHPBSLIDBDMCZ-WICJZZOFSA-N
Smiles CC1=CC=C(C=C1)NC2=NC(N[C@@H]3CCOC[C@@H]3N)=NC=C2C(N)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GSK 143

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 41.53 100
DMSO 41.53 100

Preparing Stock Solutions for GSK 143

The following data is based on the product molecular weight 415.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.04 mL 24.08 mL
5 mM 0.48 mL 2.41 mL 4.82 mL
10 mM 0.24 mL 1.2 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

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Reconstitution Calculator

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References for GSK 143

References are publications that support the biological activity of the product.

Liddle et al (2011) Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor. Bioorg.Med.Chem.Lett. 21 6188 PMID: 21903390

Varghese et al (2018) Highly selective SYK inhibitor, GSK143, abrogates survival signals in chronic lymphocytic leukaemia. Br.J.Haematol 182 927 PMID: 28770560

If you know of a relevant reference for GSK 143, please let us know.

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Citations for GSK 143

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