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GSK 2250665A

Cat. No. 5401 Submit a Review Datasheet / COA / SDS

Discontinued Product

5401 has been discontinued.

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Description: Itk inhibitor
Chemical Name: trans-4-[[4-[(6-Ethyl-2-benzothiazolyl)amino]-6-(phenylmethyl)-2-pyrimidinyl]amino]cyclohexanol
Purity: ≥97% (HPLC)
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Biological Activity Technical Data Datasheets References

Biological Activity for GSK 2250665A

GSK 2250665A is an Itk inhibitor (pKi = 9.2). Exhibits selectivity for Itk over Aurora B kinase and Btk (pIC50 values are 6.4 and 6.5, respectively) and a panel of other kinases. Inhibits IFNγ production in PBMCs.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries for GSK 2250665A

GSK 2250665A is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for GSK 2250665A

M. Wt 459.61
Formula C26H29N5OS
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 1246030-96-5
PubChem ID 73352604
InChI Key DPRNXTSMYVCYLJ-XUTJKUGGNA-N
Smiles CCC1=CC=C(N=C(NC3=NC(N[C@H]5CC[C@H](O)CC5)=NC(CC4=CC=CC=C4)=C3)S2)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for GSK 2250665A

References are publications that support the biological activity of the product.

Alder et al (2013) Identification of a novel and selective series of Itk inhibitors via a template-hopping strategy. ACS Med.Chem.Lett. 12 948 PMID: 24900590

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Keywords: GSK 2250665A, GSK 2250665A supplier, GSK2250665A, Itk, inducible, T, cell, kinase, inhibitors, inhibits, ITK, 5401, Tocris Bioscience

Citations for GSK 2250665A

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