IC 261

Discontinued Product

6676 has been discontinued.

View all Casein Kinase 1 products.
Description: CK1 inhibitor; displays selectivity for CK1δ and CK1ε
Chemical Name: 1,3-Dihydro-3-[(2,4,6-trimethoxyphenyl)methylene]-2H-indol-2-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for IC 261

IC 261 is an ATP-competitive casein kinase 1 (CK1) inhibitor. Displays >15 fold selectivity for CK1δ and CK1ε over CK1α (IC50 values are approximately 1 μM for CK1δ and CK1ε and 16 μM for CK1α). Arrests cell cycle at postmitotic G1 phase in cells expressing p53. Inhibits CK1 mediated phosphorylation of LRRK2 in cell lines.

Technical Data for IC 261

M. Wt 311.33
Formula C18H17NO4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 186611-52-9
PubChem ID 3674
InChI Key JBJYTZXCZDNOJW-UHFFFAOYSA-N
Smiles COC1=CC(OC)=C(C(OC)=C1)/C=C2C(NC3=C/2C=CC=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for IC 261

References are publications that support the biological activity of the product.

Behrend et al (2000) IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. Oncogene 19 5303 PMID: 11103931

Mashhoon et al (2000) Crystal structure of a conformation-selective casein kinase-1 inhibitor. J.Med.Chem. 275 20052 PMID: 10749871

Chia et al (2014) Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7. Nat.Commun. 5 5827 PMID: 25500533

View Related Products by Target

View Related Products by Product Action

View all Casein Kinase 1 Inhibitors

Keywords: IC 261, IC 261 supplier, IC261, casein, kinase, 1, CK1, inhibitor, inhibits, CK1delta, CK1epsilon, Casein, Kinase, 6676, Tocris Bioscience

Citations for IC 261

Citations are publications that use Tocris products.

Currently there are no citations for IC 261.

Reviews for IC 261

There are currently no reviews for this product. Be the first to review IC 261 and earn rewards!

Have you used IC 261?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets