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IND 1316

Cat. No. 7685 Submit a Review Datasheet / COA / SDS
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Description: AMPK activator
Chemical Name: 3-[3-(Phenylmethoxy)phenyl]-1H-indole-2-carboxylic acid
Purity: ≥98% (HPLC)
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Citations
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Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for IND 1316

IND 1316 is an activator of AMP-activated protein kinase (AMPK). In vitro, it activates AMPK in a dose-dependent manner and induces different MAPK pathways (p38 and JNK). In vivo, it reduces the neuropathological symptoms in two animal models of Huntington's Disease (nematodes and mice). It shows very low toxicity even at high concentrations (>200 μM). This compound is orally bioavailable.

Technical Data for IND 1316

M. Wt 343.38
Formula C22H17NO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1888473-12-8
PubChem ID 130234214
InChI Key WFARYZNGGCHILS-UHFFFAOYSA-N
Smiles OC(C1=C(C2=CC(OCC3=CC=CC=C3)=CC=C2)C4=CC=CC=C4N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for IND 1316

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.34 100
ethanol 34.34 100

Preparing Stock Solutions for IND 1316

The following data is based on the product molecular weight 343.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.91 mL 14.56 mL 29.12 mL
5 mM 0.58 mL 2.91 mL 5.82 mL
10 mM 0.29 mL 1.46 mL 2.91 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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References for IND 1316

References are publications that support the biological activity of the product.

Vela et al (2022) Neuroprotective effect of IND1316, an indole-based AMPK activator, in animal models of Huntington disease. ACS Chem.Neurosci. 13 275 PMID: 34962383

If you know of a relevant reference for IND 1316, please let us know.

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Citations for IND 1316

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Pathways for IND 1316

AMPK Signaling Pathway

AMPK Signaling Pathway

AMPK signaling pathway plays an important role in the cellular reponse to low levels of available ATP, often caused by stresses such as heat shock, ischemia or hypoxia.