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Submit ReviewK-252c
Description: Protein kinase C inhibitor
Alternative Names: Staurosporinone
Chemical Name: 6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
Purity: ≥99% (HPLC)
Biological Activity for K-252c
K-252c is an inhibitor of protein kinase C (IC50 = 2.45 μM) that displays ~ 10-fold selectivity over protein kinase A (IC50 = 25.7 μM). Also inhibits β-lactamase, malate dehydrogenase and chymotrypsin (IC50 values are 8, 8 and 10 μM respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC50 values range from 0.13 - 0.32 μM). Shows no activity against herpes simplex virus (HSV).
Technical Data for K-252c
| M. Wt | 311.34 |
| Formula | C20H13N3O |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 85753-43-1 |
| PubChem ID | 3815 |
| InChI Key | MEXUTNIFSHFQRG-UHFFFAOYSA-N |
| Smiles | O=C(NC3)C1=C3C(C4=CC=CC=C4N5)=C5C2=C1C6=C(C=CC=C6)N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for K-252c
References for K-252c
References are publications that support the biological activity of the product.
Fabre et al (1993) Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds. Bioorg.Med.Chem. 1 193 PMID: 8081852
Zimmermann et al (2000) Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase. Antiviral Res. 48 49 PMID: 11080540
McGovern and Shoichet (2003) Kinase inhibitors: not just for kinases anymore. J.Med.Chem. 46 1478 PMID: 12672248
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Keywords: K-252c, K-252c supplier, Protein, kinases, C, inhibitors, inhibits, PKC, Staurosporinone, Kinase, Cytomegalovirus, 2287, Tocris Bioscience
1 Citation for K-252c
Citations are publications that use Tocris products. Selected citations for K-252c include:
Goldman et al (2012) An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes. Chem Biol 19 855 PMID: 22840773
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