Home / Pharmacology / Enzymes / Kinases / Casein Kinase 1 / Casein Kinase 1 Inhibitors / LH 846

LH 846

Cat. No. 4896 3 Citations Submit a Review Datasheet / COA / SDS

Discontinued Product

4896 has been discontinued.

View all Casein Kinase 1 products.
Description: Selective casein kinase 1δ inhibitor
Chemical Name: N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (1)
Biological Activity Technical Data Datasheets References

Biological Activity for LH 846

LH 846 is a selective inhibitor of casein kinase (CK) 1δ (IC50 values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε and α); displays no inhibitory activity at CK2. Inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. Shown to lengthen the circadian period in U2OS cells, with minimal effect on amplitude.

Technical Data for LH 846

M. Wt 316.81
Formula C16H13ClN2OS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 639052-78-1
PubChem ID 851474
InChI Key DYHAMRNAHTWYKY-UHFFFAOYSA-N
Smiles O=C(CC3=CC=CC=C3)NC(S2)=NC1=C2C=C(C)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for LH 846

References are publications that support the biological activity of the product.

Lee et al (2011) A small molecule modulates circadian rhythms through phosphorylation of the period protein. Agnew Chem.Int.Ed.Engl. 50 10608 PMID: 21954091

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Keywords: LH 846, LH 846 supplier, LH846, casein, kinase, I, CK1, CK1d, CK1delta, CK1δ, selective, inhibitors, inhibits, circadian, rhythm, clock, Casein, Kinase, 1, 4896, Tocris Bioscience

3 Citations for LH 846

Citations are publications that use Tocris products. Selected citations for LH 846 include:

Causton et al (2015) Metabolic cycles in yeast share features conserved among circadian rhythms. Curr.Biol. 25 1056 PMID: 25866393

Zemp et al (2014) CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation. J Cell Sci 127 1242 PMID: 24424021

Greer et al (2017) Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1. PLoS One 12 e0170903 PMID: 28125685

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Literature in this Area

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Cell Cycle and DNA Damage Research Product Guide

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