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Description: Inactive analog of BIO (Cat. No. 3194)
Chemical Name: (2'Z,3'E)-6-Bromo-1-methylindirubin-3'-oxime
Purity: ≥99% (HPLC)
Biological Activity for MeBIO
MeBIO is a control analog of 6-bromoindirubin-3'-oxime (BIO). Displays minimal activity against CDK1/Cyclin B, GSK-3 α/β, and CDK5/p25 (IC50 values are 92.0, 44-100 and >100 μM respectively). Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.
Active Analog also available.
Technical Data for MeBIO
| M. Wt | 370.2 |
| Formula | C17H12BrN3O2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 667463-95-8 |
| PubChem ID | 24906281 |
| InChI Key | WWVVQXIBSZPELF-UHFFFAOYSA-N |
| Smiles | O/N=C(C1=CC=CC=C1N2)/C2=C3/C(N(C)C4=C3C=CC(Br)=C4)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MeBIO
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.7 | 10 |
Preparing Stock Solutions for MeBIO
The following data is based on the product molecular weight 370.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.01 mL | 135.06 mL | 270.12 mL |
| 0.5 mM | 5.4 mL | 27.01 mL | 54.02 mL |
| 1 mM | 2.7 mL | 13.51 mL | 27.01 mL |
| 5 mM | 0.54 mL | 2.7 mL | 5.4 mL |
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Product Datasheets for MeBIO
References for MeBIO
References are publications that support the biological activity of the product.
Knockaert et al (2004) Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins. Oncogene 23 4400 PMID: 15077192
Meijer et al (2003) GSK-3-selective inhibitors derived from tyrian purple indirubins. Chem.Biol. 10 1255 PMID: 14700633
Polychronopoulos et al (2004) Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J.Med.Chem. 47 935 PMID: 14761195
If you know of a relevant reference for MeBIO, please let us know.
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Keywords: MeBIO, MeBIO supplier, GSK-3, inhibitors, inhibits, control, Glycogen, Synthase, Kinases, 3, Carbohydrate, Metabolism, stem, cells, aryl, hydrocarbon, receptor, Kinase, Aryl, Hydrocarbon, Receptors, 3873, Tocris Bioscience
2 Citations for MeBIO
Citations are publications that use Tocris products. Selected citations for MeBIO include:
Volpini et al (2018) Trypanosoma cruzi Exploits Wnt Signaling Pathway to Promote Its Intracellular Replication in Macrophages. Front Immunol 9 859 PMID: 29743880
Diamantopoulou et al (2017) TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells. Cancer Cell 31 621 PMID: 28416184
Do you know of a great paper that uses MeBIO from Tocris? Please let us know.
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Literature in this Area
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Pathways for MeBIO
