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Submit ReviewMLR 1023
Description: Selective allosteric activator of Lyn kinase
Chemical Name: 5-(3-Methylphenoxy)-2(1H)-pyrimidinone
Purity: ≥99% (HPLC)
Biological Activity for MLR 1023
MLR 1023 is a selective allosteric activator of Lyn kinase (EC50 = 63 nM); displays no significant activity against a range of 47 other kinases, including other Src family kinases such as Fyn, Lck and Src kinase. Reduces blood glucose levels without affecting in vivo insulin secretion. Orally bioavailable.
Compound Libraries for MLR 1023
MLR 1023 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for MLR 1023
| M. Wt | 202.21 |
| Formula | C11H10N2O2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 41964-07-2 |
| PubChem ID | 39065 |
| InChI Key | HJQILFPVRNHTIG-UHFFFAOYSA-N |
| Smiles | CC1=CC(OC2=CNC(N=C2)=O)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MLR 1023
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.22 | 100 | |
| ethanol | 4.04 | 20 |
Preparing Stock Solutions for MLR 1023
The following data is based on the product molecular weight 202.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.95 mL | 24.73 mL | 49.45 mL |
| 5 mM | 0.99 mL | 4.95 mL | 9.89 mL |
| 10 mM | 0.49 mL | 2.47 mL | 4.95 mL |
| 50 mM | 0.1 mL | 0.49 mL | 0.99 mL |
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Product Datasheets for MLR 1023
References for MLR 1023
References are publications that support the biological activity of the product.
Ochman et al (2012) The Lyn kinase activator MLR-1023 is a novel Ins receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes. J.Pharmacol.Exp.Ther. 342 23 PMID: 22431203
Saporito et al (2012) MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo. J.Pharmacol.Exp.Ther. 342 15 PMID: 22473614
If you know of a relevant reference for MLR 1023, please let us know.
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Keywords: MLR 1023, MLR 1023 supplier, MLR1023, type, II, diabetes, antidiabetic, hyperglycemia, lyn, kinase, inhibitors, inhibits, selective, Src, Kinases, 4582, Tocris Bioscience
2 Citations for MLR 1023
Citations are publications that use Tocris products. Selected citations for MLR 1023 include:
Iida et al (2019) Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy. Nat Commun 10 4262 PMID: 31537808
Konstantinos et al (2021) Cdk5 and GSK3β inhibit fast endophilin-mediated endocytosis. Nat Commun 12 2424 PMID: 33893293
Do you know of a great paper that uses MLR 1023 from Tocris? Please let us know.
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