Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMps BAY 2a
Description: Potent and selective Mps1 kinase inhibitor
Chemical Name: N-Cyclopropyl-4-[8-[(2-methylpropyl)amino]-6-(5-quinolinyl)imidazo[1,2-a]pyrazin-3-yl]benzamide
Purity: ≥98% (HPLC)
Biological Activity for Mps BAY 2a
Potent and selective Mps1 inhibitor (IC50 = 1 nM for human enzyme). Selective for Mps1 over a panel of 220 kinases. Differentially inhibits human colon carcinoma cell proliferation. Blocks cell cycle progression by preventing spindle assembly checkpoint activation. Induces apoptosis.
Technical Data for Mps BAY 2a
| M. Wt | 476.57 |
| Formula | C29H28N6O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1382477-96-4 |
| PubChem ID | 57381882 |
| InChI Key | MDYKTGNHXNTATG-UHFFFAOYSA-N |
| Smiles | CC(C)CNC1=NC(C2=CC=CC3=C2C=CC=N3)=CN4C1=NC=C4C5=CC=C(C(NC6CC6)=O)C=C5 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Mps BAY 2a
References for Mps BAY 2a
References are publications that support the biological activity of the product.
Jemaà et al (2013) Characterization of novel MPS1 inhibitors with preclinical anticancer activity. Cell Death Differ. 20 1532 PMID: 23933817
View Related Products by Target
View Related Products by Product Action
Keywords: Mps BAY 2a, Mps BAY 2a supplier, MpsBAY2a, monopolar, spindle, 1, kinase, Mps1, inhibitors, inhibits, cancer, proliferation, cell, cycle, assembly, checkpoint, apoptosis, inducers, Monopolar, Spindle, Kinase, Checkpoint, Control, Kinases, 5562, Tocris Bioscience
1 Citation for Mps BAY 2a
Citations are publications that use Tocris products. Selected citations for Mps BAY 2a include:
Choi et al (2017) TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability. Br.J.Pharmacol. 174 1810 PMID: 28299790
Reviews for Mps BAY 2a
There are currently no reviews for this product. Be the first to review Mps BAY 2a and earn rewards!
Have you used Mps BAY 2a?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.