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MSC 2032964A

Cat. No. 5641 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective ASK1 inhibitor; orally bioavailable
Chemical Name: N-[5-(Cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-pyridinecarboxamide
Purity: ≥97% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for MSC 2032964A

MSC 2032964A is a potent and selective ASK1 inhibitor (IC50 = 93 nM). Selective for ASK1 over a panel of 210 kinases. Blocks LPS-induced ASK1 and p38 phosphorylation in cultured mouse astrocytes. Suppresses neuroinflammation in a mouse EAE model. Orally bioavailable and brain penetrant.

Compound Libraries for MSC 2032964A

MSC 2032964A is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for MSC 2032964A

M. Wt 362.31
Formula C16H13F3N6O
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1124381-43-6
PubChem ID 25214468
InChI Key XUKGFHHTSUKORV-UHFFFAOYSA-N
Smiles O=C(C1=CC=CN=C1)NC2=NN3C(C=C(C(F)(F)F)C=C3NC4CC4)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MSC 2032964A

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.25 20
ethanol 3.62 10 with gentle warming

Preparing Stock Solutions for MSC 2032964A

The following data is based on the product molecular weight 362.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.8 mL 69 mL 138 mL
1 mM 2.76 mL 13.8 mL 27.6 mL
2 mM 1.38 mL 6.9 mL 13.8 mL
10 mM 0.28 mL 1.38 mL 2.76 mL

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Product Datasheets for MSC 2032964A

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for MSC 2032964A

References are publications that support the biological activity of the product.

Guo et al (2010) Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Mol.Med. 2 504 PMID: 21064192

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Keywords: MSC 2032964A, MSC 2032964A supplier, MSC2032964A, apoptosis, signal, regulating, kinase, 1, ASK1, inhibits, inhibitors, potent, selective, orally, bioavailable, neuroinflammation, EAE, experimental, autoimmune, encephalomyelitis, 5641, Tocris Bioscience

2 Citations for MSC 2032964A

Citations are publications that use Tocris products. Selected citations for MSC 2032964A include:

Xochitl et al (2021) IRE1α RIDD activity induced under ER stress drives neuronal death by the degradation of 14-3-3 θ mRNA in cortical neurons during glucose deprivation. Cell Death Discov 7 131 PMID: 34083523

Ju-Ri et al (2020) IRE1α kinase-mediated unconventional protein secretion rescues misfolded CFTR and pendrin. Sci Adv 6 eaax9914 PMID: 32128399

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Literature in this Area

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