Home / Pharmacology / Enzymes / Kinases / Casein Kinase 1 / Casein Kinase 1 Inhibitors / MU 1742

MU 1742

Cat. No. 7979 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective CK1α, CK1δ and CK1ε inhibitor
Chemical Name: 4-(1-((4-Fluoro-1-methylpiperidin-4-yl)methyl)-4-(5-fluoropyridin-2-yl)-1H-imidazol-5-yl)-1H-pyrrolo[2,3-b]pyridine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for MU 1742

MU 1742 is a potent and selective casein kinase 1α (CK1α), CK1δ and CK1ε inhibitor (IC50 values are 6, 7 and 28 nM for CK1δ, CK1α and CK1ε respectively). In vivo, MU 1742 inhibits CK1δ/ε-dependent DVL3 phosphorylation in mouse lung tissue. MU 1742 is orally bioavailable.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MU 1742 probe summary on the SGC website.

Technical Data for MU 1742

M. Wt 408.46
Formula C22H22F2N6
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 167312208
InChI Key SWOIFXHMBKFCRM-UHFFFAOYSA-N
Smiles FC1=CN=C(C=C1)C2=C(C3=CC=NC4=C3C=CN4)N(CC5(F)CCN(C)CC5)C=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MU 1742

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.85 100
ethanol 40.85 100

Preparing Stock Solutions for MU 1742

The following data is based on the product molecular weight 408.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.24 mL 24.48 mL
5 mM 0.49 mL 2.45 mL 4.9 mL
10 mM 0.24 mL 1.22 mL 2.45 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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References for MU 1742

References are publications that support the biological activity of the product.

Němec et al (2023) Discovery of potent and exquisitely selective inhibitors of kinase CK1 with tunable isoform selectivity. Angew.Chem.Int.Ed.Engl. 62 e202217532 PMID: 36625768

If you know of a relevant reference for MU 1742, please let us know.

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Keywords: MU 1742, MU 1742 supplier, MU1742, casein, kinases, inhibitors, inhibits, CK1epsilon, CK1delta, CK1alpha, selective, potent, SGC, in, vivo, orally, bioavailable, CK1α, CK1δ, CK1ε, Casein, Kinase, 1, 7979, Tocris Bioscience

Citations for MU 1742

Citations are publications that use Tocris products.

Currently there are no citations for MU 1742. Do you know of a great paper that uses MU 1742 from Tocris? Please let us know.

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Literature in this Area

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