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Submit ReviewN-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu
Description: Phosphopeptide ligand for src SH2 domain
Chemical Name: N-Acetyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl]-L-α-glutamyl-L-isoleucyl]-L-glutamic acid
Biological Activity
N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu is a phosphopeptide ligand for the src SH2 domain (IC50 = 1 μM). Blocks src interactions with EGFR and FAK.
Technical Data
| M. Wt | 803.71 |
| Formula | C32H46N5O17P |
| Sequence |
YEEIE (Modifications: Tyr-1 = pTyr with C-terminal Ac) |
| Storage | Desiccate at -20°C |
| CAS Number | 159439-02-8 |
| PubChem ID | 42628614 |
| InChI Key | QQEKQSBIEKQXQS-PSCZMIBCSA-N |
| Smiles | CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CC=C(OP(O)(O)=O)C=C1)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets
Safety Datasheet is currently unavailable on-line.
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References
References are publications that support the biological activity of the product.
Gilmer et al (1994) Peptide inhibitors of src SH3-SH2-phosphoprotein interactions. J.Biol.Chem. 269 31711 PMID: 7527393
Pacofsky et al (1998) Potent dipeptide inhibitors of the pp60c-src SH2 domain. J.Med.Chem. 41 1894 PMID: 9599239
Park et al (2002) Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains. Bioorg.Med.Chem.Lett. 12 2711 PMID: 12217360
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Keywords: N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu, N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu supplier, Phosphopeptide, ligands, SH2, domain, Src, Kinases, 1927, Tocris Bioscience
Citations for N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu
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