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Description: Potent and reversible NIMA related kinase 2 (Nek2) inhibitor
Chemical Name: 3-[(6-Ethynyl-9H-purin-2-yl)amino]benzeneacetamide
Purity: ≥97% (HPLC)
Biological Activity for NCL 00017509
NCL 00017509 is a potent and reversible NIMA related kinase 2 (Nek2) inhibitor (IC50 = 56 nM). Induces increased mitotic abnormalities and mitotic delay. Cell permeable and active in vivo. In mice bearing pancreatic tumors, NCL 00017509 decreases PD-L1 expression and induces an anticancer immune response.
Technical Data for NCL 00017509
| M. Wt | 292.3 |
| Formula | C15H12N6O |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 1507367-00-1 |
| PubChem ID | 56944360 |
| InChI Key | CJQGLUJHMXCLQY-UHFFFAOYSA-N |
| Smiles | C#CC1=C2C(NC=N2)=NC(NC3=CC=CC(CC(N)=O)=C3)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NCL 00017509
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.23 | 100 |
Preparing Stock Solutions for NCL 00017509
The following data is based on the product molecular weight 292.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.42 mL | 17.11 mL | 34.21 mL |
| 5 mM | 0.68 mL | 3.42 mL | 6.84 mL |
| 10 mM | 0.34 mL | 1.71 mL | 3.42 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
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Product Datasheets for NCL 00017509
References for NCL 00017509
References are publications that support the biological activity of the product.
Lebraud et al (2014) Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles. Org.Biomol.Chem. 12 141 PMID: 24213855
Zhang et al (2021) NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1. Nat.Commun. 12 4536 PMID: 34315872
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Keywords: NCL 00017509, NCL 00017509 supplier, NCL00017509, NIMA, related, kinase, 2, NEK2, inhibitors, inhibits, mitotic, delay, Nek2, Kinase, 5150, Tocris Bioscience
1 Citation for NCL 00017509
Citations are publications that use Tocris products. Selected citations for NCL 00017509 include:
Zhang et al (2021) NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1. Nat Commun. 12 4536 PMID: 34315872
Do you know of a great paper that uses NCL 00017509 from Tocris? Please let us know.
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