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Obatoclax mesylate

Cat. No. 6539 Submit a Review Datasheet / COA / SDS
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Description: Inhibitor of Bcl-2 family members; antiapoptotic
Alternative Names: GX15-070
Chemical Name: 2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Obatoclax mesylate

Obatoclax mesylate is an inhibitor of Bcl-2 family members (IC50 values are 1.11 - 7 μM). Inhibits the interaction of a BH3 domain peptide with 6 members of the Bcl-2 family (Bcl-2, Bcl-XL, Mcl-1, Bcl-W, A1, and Bcl-B) in vitro. Has antiapoptotic and antitumor effects in several tumor bearing mouse models.

Compound Libraries for Obatoclax mesylate

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Technical Data for Obatoclax mesylate

M. Wt 413.49
Formula C20H19N3O.CH3SO3H
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 803712-79-0
PubChem ID 16681698
InChI Key ZVAGBRFUYHSUHA-LZOXOEDVSA-N
Smiles CS(O)(=O)=O.COC1=CC(C2=CC3=CC=CC=C3N2)=N/C1=C/C4=C(C=C(N4)C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Obatoclax mesylate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.67 50

Preparing Stock Solutions for Obatoclax mesylate

The following data is based on the product molecular weight 413.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.84 mL 24.18 mL 48.37 mL
2.5 mM 0.97 mL 4.84 mL 9.67 mL
5 mM 0.48 mL 2.42 mL 4.84 mL
25 mM 0.1 mL 0.48 mL 0.97 mL

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Product Datasheets for Obatoclax mesylate

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Obatoclax mesylate

References are publications that support the biological activity of the product.

Nguyen et al (2007) Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc.Natl.Acad.Sci.U.S.A. 104 19512 PMID: 18040043

Zhai et al (2006) Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins. Cell Death Differ. 13 1419 PMID: 16645636

If you know of a relevant reference for Obatoclax mesylate, please let us know.

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Citations for Obatoclax mesylate

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Literature in this Area

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Pathways for Obatoclax mesylate

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.