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Oncrasin 1

Cat. No. 3427 1 Citation Submit a Review Datasheet / COA / SDS

Discontinued Product

3427 has been discontinued.

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Description: Induces abnormal nuclear aggregation of PKCι; proapoptotic
Chemical Name: 1-[(4-Chlorophenyl)methyl]-1H-indole-3-carboxaldehyde
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Datasheets References

Biological Activity for Oncrasin 1

Oncrasin 1 is a proapoptotic agent that induces abnormal nuclear aggregation of PKCι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC50 ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo.

Technical Data for Oncrasin 1

M. Wt 269.73
Formula C16H12ClNO
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 75629-57-1
PubChem ID 872445
InChI Key ZDRQMXCSSAPUMM-UHFFFAOYSA-N
Smiles O=CC2=CN(CC3=CC=C(Cl)C=C3)C1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Oncrasin 1

References are publications that support the biological activity of the product.

Guo et al (2009) Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1). Mol.Cancer Ther. 8 441 PMID: 19208825

Guo et al (2007) Identification of a small molecule with synthetic lethality for k-Ras and protein kinase C iota. Cancer Res. 68 7403

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1 Citation for Oncrasin 1

Citations are publications that use Tocris products. Selected citations for Oncrasin 1 include:

Christopher J et al (2022) Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL. Cancer Res 82 3375-3393 PMID: 35819261

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