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P3S

Cat. No. 7974 Submit a Review Datasheet / COA / SDS
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Description: Reagent for modifying RNA at 2'-OH position, for SHAPE-MAP experiments
Chemical Name: 3-((1H-1,2,4-Triazol-1-yl)sulfonyl)pyridine
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for P3S

P3S is a pyridine sulfonyl triazole able to modify RNA via RNA 2'-OH sulfonylation. P3S can be used for RNA SHAPE-MaP experiments in cell lines or live bacteria. It is stable in aqueous media (with half-lives of several hours) even at room temperature.

Technical Data for P3S

M. Wt 210.21
Formula C7H6N4O2S
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2988852-68-0
InChI Key LBQFWDRVXUJAAR-UHFFFAOYSA-N
Smiles O=S(C1=CC=CN=C1)(N2C=NC=N2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for P3S

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.02 100

Preparing Stock Solutions for P3S

The following data is based on the product molecular weight 210.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.76 mL 23.79 mL 47.57 mL
5 mM 0.95 mL 4.76 mL 9.51 mL
10 mM 0.48 mL 2.38 mL 4.76 mL
50 mM 0.1 mL 0.48 mL 0.95 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Dilution Calculator

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References for P3S

References are publications that support the biological activity of the product.

Chatterjee et al (2023) Sulfonylation of RNA 2'-OH groups. ACS Cent.Sci. 9 531 PMID: 36968531

If you know of a relevant reference for P3S, please let us know.

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Citations for P3S

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