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PCI 29732

Cat. No. 5012 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent BTK inhibitor
Chemical Name: 1-Cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥99% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for PCI 29732

PCI 29732 is a potent BTK inhibitor (IC50 = 0.3 nM). Blocks B cell antigen receptor (BCR)-mediated gene expression in CD20+ B cells.

Compound Libraries for PCI 29732

PCI 29732 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PCI 29732

M. Wt 371.44
Formula C22H21N5O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 330786-25-9
PubChem ID 22347110
InChI Key GMJUPMONHWAZCP-UHFFFAOYSA-N
Smiles NC1=C2C(N(C4CCCC4)N=C2C3=CC=C(OC5=CC=CC=C5)C=C3)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PCI 29732

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.14 100
ethanol 18.57 50

Preparing Stock Solutions for PCI 29732

The following data is based on the product molecular weight 371.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.46 mL 26.92 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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References for PCI 29732

References are publications that support the biological activity of the product.

Honigberg et al (2010) The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc.Natl.Acad.Sci.U.S.A. 107 13075 PMID: 20615965

Krishnamurty et al (2013) Active site profiling reveals coupling between domains in SRC-family kinases. Nat.Chem.Biol. 9 43 PMID: 23143416

If you know of a relevant reference for PCI 29732, please let us know.

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Keywords: PCI 29732, PCI 29732 supplier, PCI29732, Brutons, Tyrosine, Kinase, (BTK), 5012, Tocris Bioscience

Citations for PCI 29732

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