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Submit ReviewPF 06650833
Description: Potent and selective IRAK4 inhibitor
Chemical Name: 1-[[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxo-2-pyrrolidinyl]methoxy]-7-methoxy-6-isoquinolinecarboxamide
Purity: ≥98% (HPLC)
Biological Activity for PF 06650833
PF 06650833 is a potent and selective IRAK4 inhibitor (IC50 = 2 nM). Inhibits LPS-induced TNF-α secretion in vivo. Orally bioavailable.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for PF 06650833
| M. Wt | 361.37 |
| Formula | C18H20FN3O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1817626-54-2 |
| PubChem ID | 118414016 |
| InChI Key | JKDGKIBAOAFRPJ-ZBINZKHDSA-N |
| Smiles | CC[C@H]1[C@H](NC([C@H]1F)=O)COC2=NC=CC3=C2C=C(C(C(N)=O)=C3)OC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PF 06650833
References for PF 06650833
References are publications that support the biological activity of the product.
Lee et al (2017) Discovery of clinical candidate 1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a potent, selective inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) J.Med.Chem. 60 6621 PMID: 28498658
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Keywords: PF 06650833, PF 06650833 supplier, PF06650833, IRAK4, Interleukin-1, receptor-associated, kinases, potent, selective, orally, bioavailable, IRAK, Cytokines, 6373, Tocris Bioscience
2 Citations for PF 06650833
Citations are publications that use Tocris products. Selected citations for PF 06650833 include:
Clare E et al (2022) The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways. Cell Rep 40 111225 PMID: 35977521
Jianfeng et al (2022) Interleukin-1 receptor-associated kinase 4 (IRAK4) in the nucleus accumbens regulates opioid-seeking behavior in male rats. Brain Behav Immun 101 37-48 PMID: 34958862
Reviews for PF 06650833
Average Rating: 5 (Based on 1 Review.)
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Works well for kinase assay.
By
Scott Scarneo on 02/06/2019
Assay Type: In Vitro
Species: Human
Easy to use and store. I used this assay for a kinase assay against TAK1 in vitro of purified TAK-TAB1.
