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Submit ReviewPP 121
Description: Dual kinase inhibitor; inhibits PI 3-K family kinases
Chemical Name: 1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥98% (HPLC)
Biological Activity for PP 121
PP 121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR). Exhibits no significant effect on receptor serine/threonine kinases (RSTKs). Blocks the proliferation of tumor cells by direct inhibition of PI 3-K, mTOR, Src and the VEGF receptor.
Compound Libraries for PP 121
PP 121 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for PP 121
| M. Wt | 319.36 |
| Formula | C17H17N7 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1092788-83-4 |
| PubChem ID | 24905142 |
| InChI Key | NVRXTLZYXZNATH-UHFFFAOYSA-N |
| Smiles | NC1=C2C(N(C5CCCC5)N=C2C3=CN=C(NC=C4)C4=C3)=NC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PP 121
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.94 | 100 | |
| ethanol | 15.97 | 50 |
Preparing Stock Solutions for PP 121
The following data is based on the product molecular weight 319.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.13 mL | 15.66 mL | 31.31 mL |
| 5 mM | 0.63 mL | 3.13 mL | 6.26 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.13 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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Product Datasheets for PP 121
References for PP 121
References are publications that support the biological activity of the product.
Apsel et al (2008) Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat.Chem.Biol. 4 691 PMID: 18849971
If you know of a relevant reference for PP 121, please let us know.
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Keywords: PP 121, PP 121 supplier, PP121, PI, 3-K, 3-kinase, PI3K, dual, inhibitors, inhibits, receptor, tyrosine, kinases, RTKs, 3-Kinase, mTOR, Other, 3894, Tocris Bioscience
1 Citation for PP 121
Citations are publications that use Tocris products. Selected citations for PP 121 include:
So-Youn et al (2019) Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies. Cell Death Differ 26 502-515 PMID: 29988075
Do you know of a great paper that uses PP 121 from Tocris? Please let us know.
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