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PP 121

Cat. No. 3894 1 Citation Submit a Review Datasheet / COA / SDS

Discontinued Product

3894 has been discontinued.

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Description: Dual kinase inhibitor; inhibits PI 3-K family kinases
Chemical Name: 1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Datasheets References

Biological Activity for PP 121

PP 121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR). Exhibits no significant effect on receptor serine/threonine kinases (RSTKs). Blocks the proliferation of tumor cells by direct inhibition of PI 3-K, mTOR, Src and the VEGF receptor.

Compound Libraries for PP 121

PP 121 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for PP 121

M. Wt 319.36
Formula C17H17N7
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1092788-83-4
PubChem ID 24905142
InChI Key NVRXTLZYXZNATH-UHFFFAOYSA-N
Smiles NC1=C2C(N(C5CCCC5)N=C2C3=CN=C(NC=C4)C4=C3)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for PP 121

References are publications that support the biological activity of the product.

Apsel et al (2008) Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat.Chem.Biol. 4 691 PMID: 18849971

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Keywords: PP 121, PP 121 supplier, PP121, PI, 3-K, 3-kinase, PI3K, dual, inhibitors, inhibits, receptor, tyrosine, kinases, RTKs, 3-Kinase, mTOR, Other, 3894, Tocris Bioscience

1 Citation for PP 121

Citations are publications that use Tocris products. Selected citations for PP 121 include:

So-Youn et al (2019) Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies. Cell Death Differ 26 502-515 PMID: 29988075

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