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PP 3

Cat. No. 2794 7 Citations Submit a Review Datasheet / COA / SDS
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Description: Negative control for PP 2 (Cat. No. 1407)
Chemical Name: 1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥98% (HPLC)
Datasheet
Citations (7)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for PP 3

PP 3 is a negative control for the Src kinase inhibitor, PP 2. Inhibits EGFR kinase (IC50 = 2.7 μM).

Active Analog also available.

Compound Libraries for PP 3

PP 3 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for PP 3

M. Wt 211.22
Formula C11H9N5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 5334-30-5
PubChem ID 4879
InChI Key KKDPIZPUTYIBFX-UHFFFAOYSA-N
Smiles NC1=NC=NC2=C1C=NN2C3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PP 3

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.12 100
ethanol 5.28 25

Preparing Stock Solutions for PP 3

The following data is based on the product molecular weight 211.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.73 mL 23.67 mL 47.34 mL
5 mM 0.95 mL 4.73 mL 9.47 mL
10 mM 0.47 mL 2.37 mL 4.73 mL
50 mM 0.09 mL 0.47 mL 0.95 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets for PP 3

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for PP 3

References are publications that support the biological activity of the product.

Traxler et al (1997) Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J.Med.Chem. 40 3601 PMID: 9357527

Hou et al (2007) PP2, a potent inhibitor of Src family kinases, protects against hippocampal CA1 pyramidal cell death after transient global brain ischemia. Neurosci.Letts. 420 235 PMID: 17556100

If you know of a relevant reference for PP 3, please let us know.

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7 Citations for PP 3

Citations are publications that use Tocris products. Selected citations for PP 3 include:

Li et al (2016) Progesterone receptor membrane component-1 regulates hepcidin biosynthesis. J Clin Invest 126 389 PMID: 26657863

Chen et al (2014) BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals. Eur J Neurosci 39 1439 PMID: 24611998

Vijayakumar et al (2015) Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages. Neural Regen Res 128 251 PMID: 25413351

Kubota et al (2014) mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS One 9 e106316 PMID: 25181481

Do you know of a great paper that uses PP 3 from Tocris? Please let us know.

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