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Pseudo RACK1

Cat. No. 1790 Submit a Review Datasheet / COA / SDS

Discontinued Product

1790 has been discontinued.

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Description: Protein kinase C activator peptide (attached to cell permeable vector)
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Citations
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Biological Activity Technical Data Datasheets References

Biological Activity for Pseudo RACK1

Pseudo RACK1 is an activator of protein kinase C; attached to cell permeabilization Antennapedia domain vector peptide. Consists of peptide derived from the C2 domain of PKC β linked by a disulfide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the activator peptide. Once inside the cell, the disulfide bonds are subjected to reduction in the cytoplasm leading to release of the activator peptide.

Technical Data for Pseudo RACK1

M. Wt 3198.81
Formula C144H225N43O34S3
Sequence KKWKMRRNQFWIKIQRC CSVEIWD*

(Modifcations: Disulfide bridge between 17 -1*)
Storage Store at -20°C
PubChem ID 90488710
InChI Key LTAVZZKCZYNJEE-PMCSTDROSA-N
Smiles [H]N[C@@H](CSSC[C@H](N[H])C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Pseudo RACK1

References are publications that support the biological activity of the product.

Derossi et al (1994) The third helix of the antennapedia homeodomain translocates through biological membranes. J.Biol.Chem. 269 10444 PMID: 8144628

Ron and Mochly-Rosen (1995) An autoregulatory region in protein kinase C: the pseudoanchoring site. Proc.Natl.Acad.Sci.U.S.A. 92 492 PMID: 7831317

Theodore et al (1995) Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse. J.Neurosci. 15 7158 PMID: 7472470

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Keywords: Pseudo RACK1, Pseudo RACK1 supplier, Protein, kinases, C, activators, PKC, Kinase, 1790, Tocris Bioscience

Citations for Pseudo RACK1

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