Home / Pharmacology / Enzymes / Kinases / Pim Kinase / Pim Kinase Inhibitors / R8-T198wt

R8-T198wt

Cat. No. 4592 Submit a Review Datasheet / COA / SDS

Discontinued Product

4592 has been discontinued.

View all Pim Kinase products.
Description: Pim-1 kinase inhibitor
Datasheet
Citations
Reviews
Biological Activity Technical Data Datasheets References

Biological Activity for R8-T198wt

R8-T198wt is a cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. Inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. Also inhibits Pim-1-dependent growth of DU145 cells in vitro and in vivo. Displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM.

Technical Data for R8-T198wt

M. Wt 2820.33
Formula C111H211N59O26S
Sequence GGGRRRRRRRRGCKKPGLRRRQT
Storage Store at -20°C
CAS Number 2305815-72-7
PubChem ID 90488955
InChI Key AIRNEKGCZRAELC-NBQUZRIMSA-N
Smiles [H]NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for R8-T198wt

References are publications that support the biological activity of the product.

Morishita et al (2011) Cell-permeable carboxyl-terminal p27Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase. J.Biol.Chem. 286 2681 PMID: 21062737

View Related Products by Target

View Related Products by Product Action

View all Pim Kinase Inhibitors

Keywords: R8-T198wt, R8-T198wt supplier, anticancer, prostate, cancer, Pim-1, kinases, inhibits, inhibitors, DU145, cells, cell, lines, p27Kip1, Pim, Kinase, 4592, Tocris Bioscience

Citations for R8-T198wt

Citations are publications that use Tocris products.

Currently there are no citations for R8-T198wt.

Reviews for R8-T198wt

There are currently no reviews for this product. Be the first to review R8-T198wt and earn rewards!

Have you used R8-T198wt?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review