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Submit ReviewSMER 28
Description: Positive regulator of autophagy
Chemical Name: 6-Bromo-N-2-propenyl-4-quinazolinamine
Purity: ≥99% (HPLC)
Biological Activity for SMER 28
SMER 28 is a positive regulator of autophagy in a mechanism independent from the mTOR pathway. Increases autophagosome synthesis and enhances clearance of model autophagy substrates such as mutant huntingtin and A53T α-synuclein, associated with Huntington's and Parkinson's diseases, respectively. Promotes reprogramming of fibroblasts to neural stem-like cells in combination with other chemical reagents.
Compound Libraries for SMER 28
SMER 28 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for SMER 28
| M. Wt | 264.12 |
| Formula | C11H10BrN3 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 307538-42-7 |
| PubChem ID | 1560402 |
| InChI Key | BCPOLXUSCUFDGE-UHFFFAOYSA-N |
| Smiles | C=CCNC2=NC=NC1=CC=C(Br)C=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SMER 28
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.41 | 100 |
Preparing Stock Solutions for SMER 28
The following data is based on the product molecular weight 264.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.79 mL | 18.93 mL | 37.86 mL |
| 5 mM | 0.76 mL | 3.79 mL | 7.57 mL |
| 10 mM | 0.38 mL | 1.89 mL | 3.79 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.76 mL |
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Product Datasheets for SMER 28
References for SMER 28
References are publications that support the biological activity of the product.
Renna et al (2010) Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J.Biol.Chem. 285 11061 PMID: 20147746
Sarkar et al (2010) Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat.Chem.Biol. 3 331 PMID: 17486044
Zhang et al (2016) Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell 18 653 PMID: 27133794
If you know of a relevant reference for SMER 28, please let us know.
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Keywords: SMER 28, SMER 28 supplier, SMER28, autophagy, inducer, induces, modulates, MTOR-independent, small-molecule, enhancers, SMERs, Autophagy, Stem, Cell, Reprogramming, 4297, Tocris Bioscience
5 Citations for SMER 28
Citations are publications that use Tocris products. Selected citations for SMER 28 include:
Puri et al (2018) The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A. Dev Cell 45 114 PMID: 29634932
Zhang et al (2016) Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell 18 653 PMID: 27133794
J K et al (2018) mTORC1 Controls Phase Separation and the Biophysical Properties of the Cytoplasm by Tuning Crowding. Cell 174 338-349.e20 PMID: 29937223
Cicero et al (2016) A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells. Sci Rep 6 34798 PMID: 27739443
Keith et al (2022) Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance. Nat Commun 13 4146 PMID: 35842429
Do you know of a great paper that uses SMER 28 from Tocris? Please let us know.
Reviews for SMER 28
Average Rating: 5 (Based on 1 Review.)
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Filter by:
Works good.
By
Anonymous on 06/25/2020
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Neural Stem Cells
M9 medium (10 µM SMER28)
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Autophagy Scientific Review
Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.
Autophagy Poster
Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.