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Submit ReviewSrc I1
Description: Dual site Src kinase inhibitor
Chemical Name: 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine
Purity: ≥99% (HPLC)
Biological Activity for Src I1
Src I1 is a potent, competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC50 values are 44 and 88 nM for Src and Lck respectively). Inhibits VEGFR2 and c-fms at higher concentrations (IC50 values are 0.32 and 30 μM respectively). Can be used in parallel with PP 1 (Cat. No. 1397) and PP 2 (Cat. No. 1407) to inhibit Src family kinases.
Compound Libraries for Src I1
Src I1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for Src I1
| M. Wt | 373.4 |
| Formula | C22H19N3O3 |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 179248-59-0 |
| PubChem ID | 1474853 |
| InChI Key | DMWVGXGXHPOEPT-UHFFFAOYSA-N |
| Smiles | COC(C(OC)=C3)=CC1=C3N=CN=C1NC2=CC=C(OC4=CC=CC=C4)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Src I1
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.34 | 100 |
Preparing Stock Solutions for Src I1
The following data is based on the product molecular weight 373.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.68 mL | 13.39 mL | 26.78 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.36 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.68 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
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Product Datasheets for Src I1
References for Src I1
References are publications that support the biological activity of the product.
Bain et al (2007) The selectivity of protein kinase inhibitors: a further update. Biochem.J. 408 297 PMID: 17850214
Tian et al (2001) Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines. Biochem. 40 7084 PMID: 11401553
If you know of a relevant reference for Src I1, please let us know.
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Keywords: Src I1, Src I1 supplier, Dual, site, Src, kinases, inhibitors, inhibits, Lck, family, SrcI1, Kinases, 3642, Tocris Bioscience
2 Citations for Src I1
Citations are publications that use Tocris products. Selected citations for Src I1 include:
Zhang et al (2019) CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes. BMC Immunol 20 7 PMID: 30674283
Leung et al (2015) PRL-3 mediates the protein maturation of ULBP2 by regulating the tyrosine phosphorylation of HSP60. J Immunol 194 2930 PMID: 25687758
Do you know of a great paper that uses Src I1 from Tocris? Please let us know.
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