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Submit Reviewst-Ht31
Description: Inhibits PKA/AKAP interactions; cell permeable
Purity: ≥95% (HPLC)
Biological Activity for st-Ht31
st-Ht31 is a stearated form of the peptide Ht-31. Inhibits the interaction between the RII subunits of cAMP-dependent PKA and A-kinase anchoring protein (AKAP) in cell extracts. Cell permeable.
Technical Data for st-Ht31
| M. Wt | 2798.27 |
| Formula | C129H217N29O39 |
| Sequence |
DLIEEAASRIVDAVIEQVKAAGAY (Modifications: Asp-1 = N-terminal Ste) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 188425-80-1 |
| PubChem ID | 16143012 |
| InChI Key | AHVAWKAVLPRRQS-MUBBMYIHSA-N |
| Smiles | CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for st-Ht31
| Solubility | Soluble to 1 mg/ml in 0.01M PBS (pH 7.4) |
Product Datasheets for st-Ht31
References for st-Ht31
References are publications that support the biological activity of the product.
Gorshkov et al (2017) AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons. Nat.Chem.Biol. 13 425 PMID: 28192412
Vijayaraghavan et al (1997) Protein kinase A-anchoring inhibitor peptides arrest mammalian sperm motility. J.Biol.Chem. 272 4747 PMID: 9030527
Carr et al (1992) Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain. J.Biol.Chem. 267 13376 PMID: 1618839
Stival et al (2018) Disruption of protein kinase A localization induces acrosomal exocytosis in capacitated mouse sperm. J.Biol.Chem. 293 9435 PMID: 29700114
If you know of a relevant reference for st-Ht31, please let us know.
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Keywords: st-Ht31, st-Ht31 supplier, st_Ht31, st, Ht, 31, stearated, A-kinase, anchoring, protein, AKAP, cAMP-dependent, PKA, scaffolding, proteins, Protein, Kinase, A, A-kinase-anchoring, protiens, 6286, Tocris Bioscience
2 Citations for st-Ht31
Citations are publications that use Tocris products. Selected citations for st-Ht31 include:
G Stanley et al (2022) Mislocalization of protein kinase A drives pathology in Cushing's syndrome. Cell Rep 40 111073 PMID: 35830806
Martin E et al (2020) TGFβ1 Induces Axonal Outgrowth via ALK5/PKA/SMURF1-Mediated Degradation of RhoA and Stabilization of PAR6. Eneuro 7 PMID: 32887692
Do you know of a great paper that uses st-Ht31 from Tocris? Please let us know.
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