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SU 6656

Cat. No. 6475 1 Citation Submit a Review Datasheet / COA / SDS
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Description: Potent ATP-competitive Src family kinase inhibitor; also AMPK inhibitor; cell permeable
Chemical Name: 2,3-Dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SU 6656

SU 6656 is a potent ATP-competitive Src family kinase inhibitor (IC50 values are 0.02, 0.13, 0.17, 0.28 and 6.88 nM for Yes, Lyn, Fyn, Src and Lck, respectively). Exhibits > 6.5 fold selectivity for Src family over other kinases. Also AMPK inhibitor (IC50 = 0.22 μM for the α2 kinase domain). Cell permeable.

Technical Data for SU 6656

M. Wt 371.45
Formula C19H21N3O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 330161-87-0
PubChem ID 5312137
InChI Key LOGJQOUIVKBFGH-YBEGLDIGSA-N
Smiles CN(S(=O)(C1=CC=C2NC(/C(C2=C1)=C\C3=CC4=C(N3)CCCC4)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SU 6656

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.15 100

Preparing Stock Solutions for SU 6656

The following data is based on the product molecular weight 371.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.46 mL 26.92 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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References for SU 6656

References are publications that support the biological activity of the product.

Ross et al (2017) Mechanisms of paradoxical activation of AMPK by the kinase inhibitors SU6656 and sora. Cell.Chem.Biol. 24 813 PMID: 28625738

Blake et al (2000) SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol.Cell Biol. 20 9018 PMID: 11074000

If you know of a relevant reference for SU 6656, please let us know.

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Keywords: SU 6656, SU 6656 supplier, SU6656, potent, Src, family, kinases, inhibitors, inhibits, Lck, Yes, Lyn, Fyn, AMPK, Kinases, 6475, Tocris Bioscience

1 Citation for SU 6656

Citations are publications that use Tocris products. Selected citations for SU 6656 include:

Andrii et al (2020) GDNF/RET Signaling Pathway Activation Eliminates Lewy Body Pathology in Midbrain Dopamine Neurons. Mov Disord 35 2279-2289 PMID: 32964492

Do you know of a great paper that uses SU 6656 from Tocris? Please let us know.

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