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Submit ReviewTAT-SAMβA Peptide
Description: Selective antagonist of Mfn1-βIIPKC association
Purity: ≥95% (HPLC)
Biological Activity for TAT-SAMβA Peptide
TAT-SAMβA Peptide is a selective antagonist of Mfn1-βIIPKC association. Comprises the cell permeable peptide TAT47-57, conjugated to βIIPKC624-632 by a Gly-Gly spacer. TAT-SAMβA Peptide reduces mitochondrial fragmentation and stress-induced death in cultured cardiomyocytes. In rats with heart failure, TAT-SAMβA Peptide restores mitochondrial morphology, bioenergetics, and redox balance, which leads to improvement in cardiac contractility.
Technical Data for TAT-SAMβA Peptide
| M. Wt | 2824.16 |
| Formula | C118H195N51O31 |
| Sequence | YGRKKRRQRRRGGRNAENFDRF |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| InChI Key | RGMNLQQBUQABCW-OODSNGTQSA-N |
| Smiles | O=C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCC(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2=CC=CC=C2)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC3=CC=C(C=C3)O)N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TAT-SAMβA Peptide
| Solubility | Soluble to 2 mg/ml in water |
Product Datasheets for TAT-SAMβA Peptide
References for TAT-SAMβA Peptide
References are publications that support the biological activity of the product.
Ferreira et al (2019) A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats. Nat.Commun. 10 329 PMID: 30659190
Zacharioudakis et al (2022) Mitochondrial dynamics proteins as emerging drug targets. Trends Pharmacol.Sci. 44 112 PMID: 36496299
If you know of a relevant reference for TAT-SAMβA Peptide, please let us know.
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Keywords: TAT-SAMbA Peptide, TAT-SAMbA Peptide supplier, SAMbA, SAMbetaA, peptide, antagonist, Mfn1-bIIPKC, mitochondrial, dynamics, mitochondria, TAT, SAMBA, cardiomyocytes, Mfn1, bIIPKC, betaIIPKC, Protein, Kinase, C, 7962, Tocris Bioscience
Citations for TAT-SAMβA Peptide
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