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Submit ReviewTC-DAPK 6
Description: Potent and selective inhibitor of DAPK1
Chemical Name: (4Z)-2-[(E)-2-Phenylethenyl)-4-(3-pyridinylmethylene)-5(4H)-oxazolone
Purity: ≥98% (HPLC)
Biological Activity for TC-DAPK 6
TC-DAPK 6 is a potent and selective, ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) (IC50 values are 69 and 225 nM for DAPK1 and DAPK3 respectively, when assayed with 10 μM ATP). Displays selectivity for DAPK1 over a range of 48 other kinases, including Abl, AMPK, Chk1, Met and Src (IC50 > 10 μM).
Compound Libraries for TC-DAPK 6
TC-DAPK 6 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.
Technical Data for TC-DAPK 6
| M. Wt | 276.29 |
| Formula | C17H12N2O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2439180-90-0 |
| PubChem ID | 2360773 |
| InChI Key | GFGMISOSPOPSHN-NOCYUORASA-N |
| Smiles | O=C1OC(/C=C/C3=CC=CC=C3)=N\C1=C/C2=CC=CN=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TC-DAPK 6
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 13.81 | 50 |
Preparing Stock Solutions for TC-DAPK 6
The following data is based on the product molecular weight 276.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 7.24 mL | 36.19 mL | 72.39 mL |
| 2.5 mM | 1.45 mL | 7.24 mL | 14.48 mL |
| 5 mM | 0.72 mL | 3.62 mL | 7.24 mL |
| 25 mM | 0.14 mL | 0.72 mL | 1.45 mL |
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Product Datasheets for TC-DAPK 6
References for TC-DAPK 6
References are publications that support the biological activity of the product.
Okamoto et al (2009) Identification of death-associated protein kinases inhibitors using structure-based virtual screening. J.Med.Chem. 52 7323 PMID: 19877644
If you know of a relevant reference for TC-DAPK 6, please let us know.
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Keywords: TC-DAPK 6, TC-DAPK 6 supplier, TC-DAPK6, death-associated, protein, kinase, dapk1, selective, potent, inhibitors, inhibits, 315694-89-4, DAPK, 4301, Tocris Bioscience
1 Citation for TC-DAPK 6
Citations are publications that use Tocris products. Selected citations for TC-DAPK 6 include:
Michael R et al (2020) DAPK1 Promotes Extrasynaptic GluN2B Phosphorylation and Striatal Spine Instability in the YAC128 Mouse Model of Huntington Disease. Front Cell Neurosci 14 590569 PMID: 33250715
Do you know of a great paper that uses TC-DAPK 6 from Tocris? Please let us know.
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