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TC-G 24

Cat. No. 4353 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective GSK-3β inhibitor
Chemical Name: N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TC-G 24

TC-G 24 is a potent GSK-3β inhibitor (IC50 = 17 nM); displays selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). Increases liver glycogen reserves in rodents. Brain penetrant.

Technical Data for TC-G 24

M. Wt 330.73
Formula C15H11ClN4O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1257256-44-2
PubChem ID 49857866
InChI Key JYCNWQGNEJYDQS-UHFFFAOYSA-N
Smiles CC(C=C3)=C(Cl)C=C3NC1=NN=C(C2=CC=C([N+]([O-])=O)C=C2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC-G 24

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.31 10 with gentle warming

Preparing Stock Solutions for TC-G 24

The following data is based on the product molecular weight 330.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.24 mL 151.18 mL 302.36 mL
0.5 mM 6.05 mL 30.24 mL 60.47 mL
1 mM 3.02 mL 15.12 mL 30.24 mL
5 mM 0.6 mL 3.02 mL 6.05 mL

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References for TC-G 24

References are publications that support the biological activity of the product.

Khanfar et al (2010) Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening. J.Med.Chem. 53 8534 PMID: 21082766

If you know of a relevant reference for TC-G 24, please let us know.

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Citations for TC-G 24

Citations are publications that use Tocris products.

Currently there are no citations for TC-G 24. Do you know of a great paper that uses TC-G 24 from Tocris? Please let us know.

Reviews for TC-G 24

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Literature in this Area

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Pathways for TC-G 24

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The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.