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Submit ReviewTC Mps1 12
Description: Potent and selective Mps1 kinase inhibitor
Chemical Name: 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
Purity: ≥99% (HPLC)
Biological Activity for TC Mps1 12
TC Mps1 12 is a potent and selective monopolar spindle 1 (Mps1) inhibitor (IC50 = 6.4 nM). Selective for Mps1 over a panel of 95 kinases including JNK. Inhibits A549 lung carcinoma cell proliferation and attenuates A549 cell xenograft growth in mice. Orally active.
Technical Data for TC Mps1 12
| M. Wt | 324.38 |
| Formula | C17H20N6O |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1206170-62-8 |
| PubChem ID | 70682875 |
| InChI Key | XDEFNAWAKYQBQY-UHFFFAOYSA-N |
| Smiles | NC1=C(C#N)C(NC(C)(C)C)=NC(NC2=CC=C(C(N)=O)C=C2)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TC Mps1 12
References for TC Mps1 12
References are publications that support the biological activity of the product.
Kusakabe et al (2012) Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation. ACS Med.Chem.Lett. 3 560 PMID: 24900510
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Keywords: TC Mps1 12, TC Mps1 12 supplier, TCMps112, TC, Mps1, 12, potent, selective, monopolar, spindle, 1, mps1, antitumor, orally, active, Checkpoint, Control, Kinases, Monopolar, Spindle, Kinase, 4750, Tocris Bioscience
1 Citation for TC Mps1 12
Citations are publications that use Tocris products. Selected citations for TC Mps1 12 include:
Choi et al (2017) TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability. Br.J.Pharmacol. 174 1810 PMID: 28299790
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Cell Cycle and DNA Damage Research Product Guide
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.