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Submit ReviewTCS PIM-1 4a
Description: Selective, ATP-competitive Pim kinase inhibitor
Alternative Names: SMI-4a
Chemical Name: (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
Purity: ≥98% (HPLC)
Biological Activity for TCS PIM-1 4a
Selective, ATP-competitive Pim kinase inhibitor (IC50 values are 24 and 100 nM for Pim-1 and Pim-2 respectively). Displays selectivity over a panel of ~50 other kinases tested. Exhibits cytotoxicity in PC3 prostate carcinoma cells in vitro (IC50 = 17 μM).
Technical Data for TCS PIM-1 4a
| M. Wt | 273.23 |
| Formula | C11H6F3NO2S |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 438190-29-5 |
| PubChem ID | 1361334 |
| InChI Key | NGJLOFCOEOHFKQ-YVMONPNESA-N |
| Smiles | O=C(/C(S2)=C/C1=CC(C(F)(F)F)=CC=C1)NC2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TCS PIM-1 4a
References for TCS PIM-1 4a
References are publications that support the biological activity of the product.
Xia et al (2009) Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J.Med.Chem. 52 74 PMID: 19072652
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Keywords: TCS PIM-1 4a, TCS PIM-1 4a supplier, TCSPIM14a, pim-1, pim-2, kinases, inhibitors, inhibits, selective, ATP-competitive, SMI-4a, Pim, Kinase, 3714, Tocris Bioscience
Citations for TCS PIM-1 4a
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