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Submit ReviewTG 100713
Description: PI 3-kinase inhibitor
Chemical Name: 3-(2,4-Diamino-6-pteridinyl)-phenol
Purity: ≥98% (HPLC)
Biological Activity for TG 100713
Inhibitor of PI3-kinase (IC50 values are 24, 50, 165 and 215 nM for PI3Kδ, γ, α and β isoforms respectively). Inhibits endothelial cell proliferation.
Technical Data for TG 100713
| M. Wt | 254.25 |
| Formula | C12H10N6O |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 925705-73-3 |
| PubChem ID | 17751063 |
| InChI Key | UOORQSPLBHUQDQ-UHFFFAOYSA-N |
| Smiles | NC1=NC(N)=C2C(N=CC(C3=CC=CC(O)=C3)=N2)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TG 100713
References for TG 100713
References are publications that support the biological activity of the product.
Doukas et al (2006) Phosphoinositide 3-kinase γ/δ inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proc.Natl.Acad.Sci.USA 103 19866 PMID: 17172449
Palanki et al (2007) Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction. J.Med.Chem. 50 4279 PMID: 17685602
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Keywords: TG 100713, TG 100713 supplier, TG100713, pi3k, pi3kd, pi3kdelta, pi3kδ, pi3kgamma, pi3kg, pi3kγ, pi3kalpha, pi3ka, pi3kα, pi3kbeta, pi3kb, ip3kβ, inhibitors, inhibits, PI, 3-Kinase, 4264, Tocris Bioscience
Citations for TG 100713
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