TPPB

Cat. No. 5343 6 Citations Submit a Review Datasheet / COA / SDS

Pricing	Availability		Qty

Description: High affinity PKC activator; also APP modulator

Chemical Name: (2E,4E)-N-[(2S,5S)-1,2,3,4,5,6-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3-oxo-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienamide

Purity: ≥98% (HPLC)

Datasheet

Citations (6)

Reviews

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TPPB

TPPB is a high affinity and cell permeable protein kinase C activator (K_i =11.9 nM), which induces differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells. TPPB also enhances the non-amyloidgenic processing of amyloid precursor protein, increasing secretion of sAPPα.

Technical Data for TPPB

M. Wt	501.54
Formula	C₂₇H₃₀F₃N₃O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	497259-23-1
PubChem ID	9935767
InChI Key	WOLVEMPZUIFSII-IHHOKICGSA-N
Smiles	CC([C@@H]1N(C2=CC=C(C=C2C[C@H](NC1=O)CO)NC(/C=C/C=C/C3=CC=C(C(F)(F)F)C=C3)=O)C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TPPB

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	25.08	50

Preparing Stock Solutions for TPPB

The following data is based on the product molecular weight 501.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.99 mL	19.94 mL	39.88 mL
2.5 mM	0.8 mL	3.99 mL	7.98 mL
5 mM	0.4 mL	1.99 mL	3.99 mL
25 mM	0.08 mL	0.4 mL	0.8 mL

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Product Datasheets for TPPB

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for TPPB

References are publications that support the biological activity of the product.

Rezania et al (2014) Reversal of diabetes with Ins-producing cells derived in vitro from human pluripotent stem cells. Nat.Biotechnol. 32 1121 PMID: 25211370

Chen et al (2009) A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat.Chem.Biol. 5 258 PMID: 19287398

Kozikowski et al (2003) New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPα. J.Med.Chem. 46 364 PMID: 12540236

If you know of a relevant reference for TPPB, please let us know.

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