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Description: Bcl-2 inhibitor; induces apoptosis
Chemical Name: N-[4-[[2-(1,1-Dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]benzamide
Purity: ≥97% (HPLC)
Biological Activity for TW 37
TW 37 is a Bcl-2 inhibitor (Ki values are 0.29 μM and 1.11 μM for Bcl-2 and Bcl-XL respectively). Inhibits the angiogenic potential of endothelial cells in vitro. Induces S-phase arrest and apoptosis in pancreatic cancer cell lines; also inhibits the activation of Notch-1 and Jagged-1 in vitro and in vivo.
Technical Data for TW 37
| M. Wt | 573.7 |
| Formula | C33H35NO6S |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 877877-35-5 |
| PubChem ID | 11455910 |
| InChI Key | PQAPVTKIEGUPRN-UHFFFAOYSA-N |
| Smiles | OC1=C(CC2=C(C(C)C)C=CC=C2)C=C(C(NC3=CC=C(S(C4=C(C(C)(C)C)C=CC=C4)(=O)=O)C=C3)=O)C(O)=C1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TW 37
References for TW 37
References are publications that support the biological activity of the product.
Wang et al (2006) Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J.Med.Chem. 49 6139 PMID: 17034116
Zeitlin et al (2006) Antiangiogenic effect of TW37, a small-molecule inhibitor of Bcl-2. Cancer Res. 66 8698 PMID: 16951185
Ashimori et al (2009) TW-37, a small molecule inhibitor of Bcl-2, mediates S phase cell cycle arrest and suppresses head and neck tumor angiogenesis. Mol.Cancer.Ther. 8 893 PMID: 19372562
Wang et al (2009) TW-37, a small molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway. Cancer Res. 69 2757 PMID: 19318573
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Keywords: TW 37, TW 37 supplier, bcl-2, inhibitors, inhibits, proapoptotic, apoptosis, inducers, TW37, Bcl-2, Family, Apoptosis, Inducers, 4038, Tocris Bioscience
1 Citation for TW 37
Citations are publications that use Tocris products. Selected citations for TW 37 include:
Majeed et al (2019) Potent and PPARα-independent anti-proliferative action of the hypolipidemic drug FBT in VEGF-dependent angiosarcomas in vitro. Sci Rep 9 6316 PMID: 31004117
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for TW 37
