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Submit ReviewTWS 119
Discontinued Product
This product has been withdrawn from sale and is superseded by TWS 119 (Cat. No. 7405)
Description: GSK-3β inhibitor; induces neuronal differentiation in ESCs
Chemical Name: 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxyphenol ditrifluoroacetate
Purity: ≥98% (HPLC)
Biological Activity for TWS 119
TWS 119 is an inhibitor of glycogen synthase kinase-3β (IC50 = 30 nM). Induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs).
Technical Data for TWS 119
| M. Wt | 546.38 |
| Formula | C18H14N4O2.2CF3CO2H |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1507095-58-0 |
| PubChem ID | 90488884 |
| InChI Key | XJEFPMFFWJTJSL-UHFFFAOYSA-N |
| Smiles | FC(F)(F)C(O)=O.OC1=CC=CC(OC2=C3C(NC(C4=CC=CC(N)=C4)=C3)=NC=N2)=C1.FC(F)(F)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TWS 119
References for TWS 119
References are publications that support the biological activity of the product.
Ding et al (2003) Synthetic small molecules that control stem cell fate. Proc.Natl.Acad.Sci. 100 7632
Kordes et al (2008) Canonical wnt signaling maintains the quiescent stage of hepatic stellate cells. Biochem.Biophys.Res.Comm. 367 116
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Keywords: TWS 119, TWS 119 supplier, TWS119, stem, cells, glycogen, synthase, kinases, gsk-3, gsk3, gsk-3b, gsk-3beta, gsk-3β, inhibitors, inhibits, neuronal, differentiation, Glycogen, Synthase, Kinase, 3, ESCs, and, iPSC, Neural, Stem, Cells, 3835, Tocris Bioscience
Citations for TWS 119
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Currently there are no citations for TWS 119.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
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Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.
Pathways for TWS 119
