Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewXIE62-1004
Description: Inducer of autophagy via interaction of p62 and LC3
Chemical Name: 2-[[[3,4-Bis(phenylmethoxy)phenyl]methyl]amino]ethanol hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for XIE62-1004
XIE62-1004 is an inducer of p62-LC3 interaction. Binds to the ZZ domain of p62, leading to p62 self-aggregation and interaction with LC3 on autophagosome membranes; facilitates delivery of cargo proteins to the autophagosome for degradation. Active in vitro and in vivo in a concentration- and time-dependent manner and is specific for wild type p62. Induces degradation of mutant huntingtin in vitro. Can also be used in AUTAC protein degradation systems to induce autophagy through p62 self-aggregation and LC3 interaction.
Technical Data for XIE62-1004
| M. Wt | 399.91 |
| Formula | C23H25NO3.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2421146-32-7 |
| PubChem ID | 126601715 |
| InChI Key | ROURICFSUKPJOO-UHFFFAOYSA-N |
| Smiles | Cl.OCCNCC1=CC=C(OCC=2C=CC=CC2)C(OCC=3C=CC=CC3)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for XIE62-1004
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8 | 20 |
Preparing Stock Solutions for XIE62-1004
The following data is based on the product molecular weight 399.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.5 mL | 62.51 mL | 125.03 mL |
| 1 mM | 2.5 mL | 12.5 mL | 25.01 mL |
| 2 mM | 1.25 mL | 6.25 mL | 12.5 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.5 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for XIE62-1004
References for XIE62-1004
References are publications that support the biological activity of the product.
Zhang et al (2018) ZZ-dependent regulation of p62/SQSTM1 in autophagy. Nat.Commun. 9 4373 PMID: 30349045
Cha-Molstad et al (2017) p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis. Nat.Commun. 8 102 PMID: 28740232
If you know of a relevant reference for XIE62-1004, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: XIE62-1004, XIE62-1004 supplier, XIE621004, p62, LC3, p62zz, zz, domain, autophagosome, degrader, degradation, degrade, degrades, mutant, AUTAC, huntingtin, Autophagy, Protein, Dimerizers, 7878, Tocris Bioscience
Citations for XIE62-1004
Citations are publications that use Tocris products.
Currently there are no citations for XIE62-1004. Do you know of a great paper that uses XIE62-1004 from Tocris? Please let us know.
Reviews for XIE62-1004
There are currently no reviews for this product. Be the first to review XIE62-1004 and earn rewards!
Have you used XIE62-1004?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Autophagy Scientific Review
Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.
Autophagy Poster
Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.