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Description: Potent Ack1/TNK2 inhibitor
Chemical Name: 5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
Purity: ≥98% (HPLC)
Biological Activity for XMD 8-87
XMD 8-87 is a potent Ack1/TNK2 inhibitor (IC50 = 38 and 113 nM in Ba/F3 cell lines containing leukemia-associated D163E and R806Q mutations respectively). Blocks phosphorylation of TNK2 receptors containing solid-tumor type truncation mutations.
Licensing Information
Sold under license from Dana-Farber Cancer Institute.
Technical Data for XMD 8-87
| M. Wt | 445.52 |
| Formula | C24H27N7O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1234480-46-6 |
| PubChem ID | 53322923 |
| InChI Key | LGLHCXISMKHLIK-UHFFFAOYSA-N |
| Smiles | COC1=C(C=CC(N2CCN(CC2)C)=C1)NC3=NC=C4NC(C5=CC=CC=C5N(C4=N3)C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for XMD 8-87
References for XMD 8-87
References are publications that support the biological activity of the product.
Maxson et al (2015) Identification and characterization of tyrosine kinase nonreceptor 2 mutations in leukemia through integration of kinase inhibitor screening and genomic analysis. Cancer.Res. 76 127 PMID: 26677978
Maxson et al (2014) Development and repurposing of small-molecule kinase inhibitors to target novel leukemogenic TNK2 mutations Blood 124 435
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Keywords: XMD 8-87, XMD 8-87 supplier, XMD8-87, Inhibitors, inhibits, Ack1, TNK2, Ba/F3, leukemia, D163E, R806Q, phosphorylation, tyrosine, kinase, 2, 6061, Tocris Bioscience
Citations for XMD 8-87
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Currently there are no citations for XMD 8-87.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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