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Description: PFKFB3 inhibitor
Chemical Name: Ethyl 7-hydroxy-2-oxo-2H-1-benzopyran-3-carboxylate
Purity: ≥98% (HPLC)
Biological Activity for YZ9
YZ9 is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor (IC50 = 0.183 μM). Also competitively inhibits F-6-P (Ki = 0.094 μM). Inhibits cell growth (GI50 = 2.7 μM) in a XTT-based in vitro toxicology assay.
Technical Data for YZ9
| M. Wt | 234.2 |
| Formula | C12H10O5 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 6093-71-6 |
| PubChem ID | 5289613 |
| InChI Key | IETDBZQIWIJQJG-UHFFFAOYSA-N |
| Smiles | O=C2C(C(OCC)=O)=CC1=CC=C(O)C=C1O2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for YZ9
References for YZ9
References are publications that support the biological activity of the product.
Seo et al (2011) Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect. PLoS One 6 e24179 PMID: 21957443
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Keywords: YZ9, YZ9 supplier, PFKFB3, inhibitors, inhibits, phosphofructo, kinase, fructose, bifunctional, enzymes, growth, cancer, glycolysis, warburg, 5048, Tocris Bioscience
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