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ZLN 024 hydrochloride

Cat. No. 5285 2 Citations Submit a Review Datasheet / COA / SDS

Discontinued Product

5285 has been discontinued.

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Description: Allosteric AMPK activator
Chemical Name: 2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]pyrimidine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for ZLN 024 hydrochloride

ZLN 024 hydrochloride is an allosteric AMP-activated protein kinase (AMPK) activator; allosterically stimulates active AMPK heterotrimers, increasing the activity of α1β1γ1 by 1.5-fold and α2β1γ1 by 1.7-fold (EC50 values are 0.42 and 0.95 μM, respectively). Inhibits dephosphorylation of AMPK Thr-172 by PP2Cα. Stimulates glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio. Also decreases fatty acid synthesis and glucose output in primary hepatocytes. Improves glucose tolerance and decreases cholesterol content in db/db mice.

Technical Data for ZLN 024 hydrochloride

M. Wt 361.69
Formula C13H13BrN2OS.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1883548-91-1
PubChem ID 91654626
InChI Key MMQCYIMDROWWFE-UHFFFAOYSA-N
Smiles BrC1=C(OCCSC2=NC=CC=N2)C=CC(C)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for ZLN 024 hydrochloride

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for ZLN 024 hydrochloride

References are publications that support the biological activity of the product.

Li et al (2013) Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice. Toxicol.Appl.Pharmacol. 273 325 PMID: 24055643

Zhang et al (2013) Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One 8 e72092 PMID: 23977216

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2 Citations for ZLN 024 hydrochloride

Citations are publications that use Tocris products. Selected citations for ZLN 024 hydrochloride include:

Toby et al (2020) The influence of hypoxia and energy depletion on the response of endothelial cells to the vascular disrupting agent combretastatin A-4-phosphate. Sci Rep 10 9926 PMID: 32555222

Eric et al (2020) Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB. Mol Cell 77 875-886.e7 PMID: 31836389

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Pathways for ZLN 024 hydrochloride

AMPK Signaling Pathway

AMPK Signaling Pathway

AMPK signaling pathway plays an important role in the cellular reponse to low levels of available ATP, often caused by stresses such as heat shock, ischemia or hypoxia.