1-Naphthyl PP1

Cat. No. 3063 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Src family kinase inhibitor; also inhibits c-Abl

别名： 1-NA-PP 1

化学名： 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

纯度： ≥99% (HPLC)

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 1-Naphthyl PP1

1-Naphthyl PP1 is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC₅₀ values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC₅₀ values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).

化合物库 for 1-Naphthyl PP1

1-Naphthyl PP1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for 1-Naphthyl PP1

分子量	317.39
公式	C₁₉H₁₉N₅
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	221243-82-9
PubChem ID	4877
InChI Key	XSHQBIXMLULFEV-UHFFFAOYSA-N
Smiles	NC1=NC=NC2=C1C(C3=C4C(C=CC=C4)=CC=C3)=NN2C(C)(C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 1-Naphthyl PP1

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	6.35	20

制备储备液 for 1-Naphthyl PP1

以下数据基于产品分子量 317.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	15.75 mL	78.77 mL	157.53 mL
1 mM	3.15 mL	15.75 mL	31.51 mL
2 mM	1.58 mL	7.88 mL	15.75 mL
10 mM	0.32 mL	1.58 mL	3.15 mL

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产品说明书 for 1-Naphthyl PP1

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 1-Naphthyl PP1

参考文献是支持产品生物活性的出版物。

Bishop et al (2000) A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407 395 PMID: 11014197

Bishop et al (1999) Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J.Am.Chem.Soc. 121 627

If you know of a relevant reference for 1-Naphthyl PP1, please let us know.

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