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1,6-Hexanediol

Cat. No. 7046 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Tool for probing liquid-liquid phase separation
纯度： ≥98%
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 1,6-Hexanediol

1,6-Hexanediol is a widely used tool to probe liquid-liquid phase separation (LLPS) in cells. Disrupts hydrophobic interaction-induced phase separation assemblies both in vitro and in vivo. Dissolves LLPS condensates, such as P bodies, but not solid-like condensates, such as protein aggregates and cytoskeletal assemblies.Typically used as a 3-10% solution (w/v). Disrupts cellular structures in yeast and alters cellular morphology in HeLa cells.

技术数据 for 1,6-Hexanediol

分子量 118.18
公式 C6H14O2
储存 Store at RT
纯度 ≥98%
CAS Number 629-11-8
PubChem ID 12374
InChI Key XXMIOPMDWAUFGU-UHFFFAOYSA-N
Smiles OCCCCCCO

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 1,6-Hexanediol

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 11.82 100
DMSO 11.82 100

制备储备液 for 1,6-Hexanediol

以下数据基于产品分子量 118.18。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 8.46 mL 42.31 mL 84.62 mL
5 mM 1.69 mL 8.46 mL 16.92 mL
10 mM 0.85 mL 4.23 mL 8.46 mL
50 mM 0.17 mL 0.85 mL 1.69 mL

Molarity Calculator

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Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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产品说明书 for 1,6-Hexanediol

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for 1,6-Hexanediol

参考文献是支持产品生物活性的出版物。

Shan et al (2018) Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division. Nat.Commun. 9 737 PMID: 29467404

Wheeler et al (2016) Distinct stages in stress granule assembly and disassembly. Elife 5 e18413 PMID: 27602576

Kroschwald et al (2017) Hexanediol: a chemical probe to investigate the material properties of membrane-less compartments. Matters

If you know of a relevant reference for 1,6-Hexanediol, please let us know.

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关键词: 1,6-Hexanediol, 1,6-Hexanediol supplier, liquid-liquid, phase, separation, LLPS, liquid-like, solid-like, assemblies, probe, membrane-less, compartments, disrupts, dissolves, Biochemicals, and, Molecular, Biology, 7046, Tocris Bioscience

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