2-Deoxy-D-glucose

Name: 2-Deoxy- D -glucose
Brand: Tocris Bioscience
SKU: 4515
Rating: 4.7 (3 reviews)

Cat. No. 4515 2 篇引用文献 3 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Non-metabolizable glucose analog; inhibits glucose metabolism

化学名： 2-Deoxy-D-arabino-hexose

说明书

引用文献 (2)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 2-Deoxy-D-glucose

2-Deoxy-D-glucose is a non-metabolizable glucose analog. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Also inhibits phosphoglucose isomerase (PGI) competitively. Causes cell cycle inhibition and cell death in in vitro models of hypoxia; blocks tumor cell growth in animal models. Also shown to induce the unfolded protein response (UPR). 2-Deoxy-D-glucose disrupts N-glycan expression on the surface of pancreatic adenocarcinoma cells. 2-Deoxy-D-glucose enhances chimeric antigen receptor T cell activity in different xenograft mouse models of pancreatic adenocarcinoma cells.

技术数据 for 2-Deoxy-D-glucose

分子量	164.16
公式	C₆H₁₂O₅
储存	Store at +4°C
CAS Number	154-17-6
PubChem ID	439268
InChI Key	PMMURAAUARKVCB-CERMHHMHSA-N
Smiles	OC1C[C@@H](O)[C@H](O)[C@@H](CO)O1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 2-Deoxy-D-glucose

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	16.42	100
	DMSO	16.42	100

制备储备液 for 2-Deoxy-D-glucose

以下数据基于产品分子量 164.16。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	6.09 mL	30.46 mL	60.92 mL
5 mM	1.22 mL	6.09 mL	12.18 mL
10 mM	0.61 mL	3.05 mL	6.09 mL
50 mM	0.12 mL	0.61 mL	1.22 mL

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产品说明书 for 2-Deoxy-D-glucose

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 2-Deoxy-D-glucose

参考文献是支持产品生物活性的出版物。

Kang and Hwang (2006) 2-deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low glucose mimetic. Life Sci. 78 1392 PMID: 16111712

Maher et al (2004) Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions. Cancer Chemother.Pharmacol. 53 116 PMID: 14605866

Ralser et al (2008) A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth. Proc.Natl.Acad.Sci.USA 105 17807 PMID: 19004802

Greco et al (2022) Disrupting N-glycan expression on tumor cells boosts chimeric antigen receptor T cell efficacy against solid malignancies. Sci.Transl.Med. 14 3072 PMID: 35044789

If you know of a relevant reference for 2-Deoxy-D-glucose, please let us know.

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关键词: 2-Deoxy-D-glucose, 2-Deoxy-D-glucose supplier, non-metabolizable, hexokinase, substrates, hypoxia, hypoxic, cell, growth, inhibitors, inhibits, inhibition, Hexokinases, Enzyme, Substrates, /, Activators, Other, ER, stress/UPR, 4515, Tocris Bioscience

2 篇 2-Deoxy-D-glucose 的引用文献

引用文献是使用了 Tocris 产品的出版物。 2-Deoxy-D-glucose 的部分引用包括：

Lin et al (2017) Lactate-activated macrophages induced aerobic glycolysis and epithelial-mesenchymal transition in breast cancer by regulation of CCL5-CCR5 axis: a positive metabolic feedback loop. Oncotarget 8 110426 PMID: 29299159

Beas et al (2020) A ventrolateral medulla-midline thalamic circuit for hypoglycemic feeding. Nat.Commun. 11 6218 PMID: 33277492

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2-Deoxy-D-glucose 的评论

平均评分: 4.7 (基于 3 条评论。)

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Good quality for in vitro study.

By Anonymous on 03/07/2020

分析类型： In Vitro

种属： Human

细胞系/组织： MDA-MB-231

2-DG (10mM) was used to inhibit the glycolytic pathway in MDA-MB-231 cell lines.

Blockade of glycolysis at 5 mM enhances lipid peroxidation.

By Anonymous on 02/27/2020

分析类型： In Vitro

种属： Human

细胞系/组织： human cancer lines

Used to inhibit glycolysis and influence activity of a lipid peroxidation enzyme. Good activity was observed at 5 mM with the majority of cell lines surviving. We found a few cancer cell lines where 5 uM was cytotoxic

Dissolved in PBS to 500 mM. Suggest ordering a large size as it goes by quickly at 5mM.

Glycolysis block.

By Anonymous on 01/31/2018

分析类型： Ex Vivo

种属： Mouse

细胞系/组织： acute brain slice

Used in brain slices to block glycolysis. Effect observed on cells within minutes of bulk application, as expected.

该领域的文献

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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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