2A3

Cat. No. 7376 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Reagent for RNA SHAPE-MaP experiments in vivo; cell permeable

化学名： (2-Aminopyridin-3-yl)(1H-imidazol-1-yl)methanone

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 2A3

2A3 is an electrophilic chemical probe that acylates the 2'-OH in the RNA backbone. 2A3 can be used for RNA SHAPE-MaP experiments in cell lines or live bacteria. It labels single-stranded or flexible regions more than folded regions (SHAPE methodology) and enables analysis of RNA secondary structures at single nucleotide resolution. For intracellular experiments, 2A3 has higher signal-to-noise ratio and prediction accuracy than NAI (Cat. No. 7004). 2A3 is cell permeable, and can probe both gram-positive and gram-negative bacteria.

许可信息

Sold with kind permission of Dr Danny Incarnato

技术数据 for 2A3

分子量	188.19
公式	C₉H₈N₄O
储存	Store at -20°C
CAS Number	2765091-45-8
InChI Key	HTSCLDQAVWRITQ-UHFFFAOYSA-N
Smiles	O=C(N1C=NC=C1)C2=CC=CN=C2N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 2A3

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	18.82	100

制备储备液 for 2A3

以下数据基于产品分子量 188.19。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	5.31 mL	26.57 mL	53.14 mL
5 mM	1.06 mL	5.31 mL	10.63 mL
10 mM	0.53 mL	2.66 mL	5.31 mL
50 mM	0.11 mL	0.53 mL	1.06 mL

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产品说明书 for 2A3

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 2A3

参考文献是支持产品生物活性的出版物。

Marinus et al (2021) A novel SHAPE reagent enables the analysis of RNA structure in living cells with unprecedented accuracy. Nucleic Acids Res. 49 e34 PMID: 33398343

If you know of a relevant reference for 2A3, please let us know.

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关键词: 2A3, 2A3 supplier, Reagent, RNA, SHAPE, MaP, chemistry, experiments, 1methyl7nitroisatoic, mapping, secondary, tertiary, structures, cell, permeable, in, vivo, DNA,, and, Protein, Synthesis, Biochemicals, Molecular, Biology, 7376, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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2A3