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740 Y-P

Cat. No. 1983 10 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Cell-permeable PI 3-kinase activator
别名： PDGFR740Y-P
纯度： ≥85% (HPLC)
说明书
引用文献 (10)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 740 Y-P

740 Y-P is a cell-permeable phosphopeptide activator of PI 3-kinase. Binds with high affinity to p85 subunit of the enzyme. Displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro.

技术数据 for 740 Y-P

分子量 3270.72
公式 C141H222N43O39PS3
序列 RQIKIWFQNRRMKWKKSDGGYMDMS

(Modifications: Tyr-21 = pTyr)
储存 Store at -20°C
纯度 ≥85% (HPLC)
CAS Number 1236188-16-1
PubChem ID 90488730
InChI Key XCGMILZGRGEWHL-QYGSNONCSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=C(OP(O)(O)=O)C=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 740 Y-P

溶解性 Soluble to 1 mg/ml in water

产品说明书 for 740 Y-P

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for 740 Y-P

参考文献是支持产品生物活性的出版物。

Williams and Doherty (1999) Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway. Mol.Cell.Neurosci. 13 272 PMID: 10328886

Derossi et al (1998) Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem.Biophys.Res.Comm. 251 148

If you know of a relevant reference for 740 Y-P, please let us know.

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关键词: 740 Y-P, 740 Y-P supplier, Cell-permeable, PI, 3-kinase, activators, PI3K, 740YP, phosphopeptide, activator, p85, PDGFR740Y-P, 3-Kinase, Inositol, Lipids, Enzyme, Substrates, /, Activators, 1983, Tocris Bioscience

10 篇 740 Y-P 的引用文献

引用文献是使用了 Tocris 产品的出版物。 740 Y-P 的部分引用包括：

Sun et al (2015) Thyroid hormone inhibits the proliferation of piglet Sertoli cell via PI3K signaling pathway. J Assist Reprod Genet 83 86 PMID: 25284282

Li et al (2010) Activation of dormant ovarian follicles to generate mature eggs. Nat Commun 107 10280 PMID: 20479243

Drelich et al (2018) Exchange Protein Directly Activated by cAMP Modulates Ebola Virus Uptake into Vascular Endothelial Cells. Viruses 10 PMID: 30332733

Sun et al (2015) New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators. Cell Cycle 14 721 PMID: 25590233

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740 Y-P 的评论

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in vitro PI3K activation.
By Anonymous on 07/12/2018
分析类型： In Vitro
种属： Human
细胞系/组织： MCF10A

Added in culture medium to promote PI3K pathway

Not sure if it is working or notWish larger amounts with discount were available