A 1070722

Cat. No. 4431 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Highly potent, selective GSK-3 inhibitor

化学名： 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea

纯度： ≥99% (HPLC)

文献 (4)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for A 1070722

A 1070722 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor (K_i = 0.6 nM for GSK-3α and GSK-3β). Displays high selectivity (> 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Decreases phosphorylation of microtubule-associated protein Tau in vitro; protects rat primary cortical neurons against β amyloid and glutamate challenge. Brain penetrant.

化合物库 for A 1070722

A 1070722 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for A 1070722

分子量	362.31
公式	C₁₇H₁₃F₃N₄O₂
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	1384424-80-9
PubChem ID	49830684
InChI Key	VQPBIJGXSXEOCU-UHFFFAOYSA-N
Smiles	O=C(NC3=NC(C(F)(F)F)=CC=C3)NC2=CC=NC1=CC(OC)=CC=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for A 1070722

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	36.23	100

制备储备液 for A 1070722

以下数据基于产品分子量 362.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.76 mL	13.8 mL	27.6 mL
5 mM	0.55 mL	2.76 mL	5.52 mL
10 mM	0.28 mL	1.38 mL	2.76 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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产品说明书 for A 1070722

分析证书/产品说明书

化学品安全技术说明书

参考文献 for A 1070722

参考文献是支持产品生物活性的出版物。

Bakker et al (2011) A-1070722, a potent, selective, and centrally active glycogen synthase kinase-3 (GSK-3) inhibitor for the treatment of psychiatric and neurodegenerative disorders. Society for Neuroscience (Abstract) 568

If you know of a relevant reference for A 1070722, please let us know.

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关键词: A 1070722, A 1070722 supplier, A1070722, glycogen, synthase, kinases, 3, inhibits, inhibitors, potent, selective, brain, penetrant, neuroprotective, tau, phosphorylation, beta, b, amyloid, Glycogen, Synthase, Kinase, 4431, Tocris Bioscience

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