Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewA 410099.1
说明： High affinity XIAP antagonist; active in vivo
化学名： N-Methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-L-prolinamide hydrochloride
纯度： ≥98% (HPLC)
生物活性 for A 410099.1
A 410099.1 is a high affinity XIAP antagonist (Kd = 16 nM for the BIR3 domain of XIAP). Exhibits cytotoxicity in a wide range of cancer cell lines in vitro (EC50 = 13 nM in MDA-MB-231 cells). Also displays antitumor activity in a mouse breast cancer xenograft model. Enhances TRAIL-induced apoptosis in chronic lymphocytic leukemia (CLL) cells.
化合物库 for A 410099.1
A 410099.1 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for A 410099.1
| 分子量 | 505.09 |
| 公式 | C27H40N4O3.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 762274-58-8 |
| PubChem ID | 131858992 |
| InChI Key | OPCYOBWCDDJCFT-VOSOYEAFSA-N |
| Smiles | CN[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@@H]2CCCC3=CC=CC=C23)=O)=O)C4CCCCC4)=O)C.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for A 410099.1
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 50.51 | 100 | |
| DMSO | 50.51 | 100 |
制备储备液 for A 410099.1
以下数据基于产品分子量 505.09。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.98 mL | 9.9 mL | 19.8 mL |
| 5 mM | 0.4 mL | 1.98 mL | 3.96 mL |
| 10 mM | 0.2 mL | 0.99 mL | 1.98 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for A 410099.1
参考文献 for A 410099.1
参考文献是支持产品生物活性的出版物。
Oost et al (2004) Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer. J.Med.Chem. 47 4417 PMID: 15317454
Loeder et al (2009) A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia. Cancer Res. 69 8977 PMID: 19920200
If you know of a relevant reference for A 410099.1, please let us know.
按标靶查看相关产品
按产品操作查看相关产品
关键词: A 410099.1, A 410099.1 supplier, A410099.1, A4100991, XIAP, antagonists, antagonism, inhibitors, inhibits, high, affinity, x-linked, inhibitor, of, apoptosis, IAP, anticancer, Inhibitor, Apoptosis, (IAP), 6470, Tocris Bioscience
1 篇 A 410099.1 的引用文献
引用文献是使用了 Tocris 产品的出版物。 A 410099.1 的部分引用包括：
Susanne et al (2022) A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins. Front Cell Dev Biol 10 886537 PMID: 35721509
您是否知道使用了 Tocris A 410099.1 的优秀论文？ 请告知我们.
A 410099.1 的评论
目前没有该产品的评论。 Be the first to review A 410099.1 and earn rewards!
Have you used A 410099.1?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for A 410099.1
