A 419259 trihydrochloride

Name: A 419259 trihydrochloride
Brand: Tocris Bioscience
SKU: 3914
Rating: 5 (1 reviews)

Cat. No. 3914 6 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Inhibitor of Src family kinases

化学名： 7-[trans-4-(4-Methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-Pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for A 419259 trihydrochloride

A 419259 trihydrochloride is a potent Hck inhibitor (IC₅₀ = 0.43 nM). Also inhibits other Src family kinases (SFKs). Suppresses proliferation and induces apoptosis in CML cell lines including CD34⁺. Also inhibits acute myeloid leukemia (AML) stem cell proliferation in vitro and in vivo.

化合物库 for A 419259 trihydrochloride

A 419259 trihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for A 419259 trihydrochloride

分子量	592.01
公式	C₂₉H₃₄N₆O.3HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	1435934-25-0
PubChem ID	76848881
InChI Key	ALRMEQIQFCUAMR-UHFFFAOYSA-N
Smiles	NC1=C2C(N([C@H]5CC[C@H](N6CCN(C)CC6)CC5)C=C2C3=CC=C(OC4=CC=CC=C4)C=C3)=NC=N1.Cl.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for A 419259 trihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	59.2	100
	DMSO	11.84	20

制备储备液 for A 419259 trihydrochloride

以下数据基于产品分子量 592.01。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.69 mL	8.45 mL	16.89 mL
5 mM	0.34 mL	1.69 mL	3.38 mL
10 mM	0.17 mL	0.84 mL	1.69 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for A 419259 trihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for A 419259 trihydrochloride

参考文献是支持产品生物活性的出版物。

Wilson et al (2002) Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene 21 8075 PMID: 12444544

Pene-Dumitrescu et al (2008) An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad spectrum Src family kinase inhibitor A-419259. Oncogene 27 7055 PMID: 18794796

Saito et al (2013) A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo. Sci.Transl.Med. 5 PMID: 23596204

If you know of a relevant reference for A 419259 trihydrochloride, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Src Kinase Inhibitors

关键词: A 419259 trihydrochloride, A 419259 trihydrochloride supplier, A419259, Src, family, kinase, SFK, inhibitors, inhibits, apoptosis, inducers, trihydrochloride, 3HCl, lck, Hck, Kinases, 3914, Tocris Bioscience