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A01

Cat. No. 5397 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5397 has been discontinued.

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说明： High affinity Smurf1 inhibitor; enhances BMP signaling
化学名： [4-[[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone
纯度： ≥98% (HPLC)
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引用文献
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文献 (3)
生物活性 技术数据 说明书 参考文献

生物活性 for A01

A01 is a high affinity Smurf1 E3 ubiquitin ligase inhibitor (Kd = 3.7 nM). Attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. Potentiates BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells.

技术数据 for A01

分子量 512.93
公式 C22H20ClF3N4O3S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1007647-73-5
PubChem ID 17555704
InChI Key QFYLTUDRXBNZFQ-UHFFFAOYSA-N
Smiles ClC1=C(C(F)(F)F)C=C(S(N2CCN(C(C3=CC=C(N4C(C)=CC=N4)C=C3)=O)CC2)(=O)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for A01

参考文献是支持产品生物活性的出版物。

Cao et al (2014) Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. Sci.Rep. 4 4965 PMID: 24828823

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关键词: A01, A01 supplier, A01, bone, morphogenetic, proteins, high, affinity, smurf1, e3, ubiquitin, ligase, inhibitors, inhibits, smad, osteoblasts, BMP, and, Other, Activin, Receptors, Ubiquitin, E3, Ligases, 5397, Tocris Bioscience

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