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ABT 263

Cat. No. 7680 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor
化学名： 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (2)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ABT 263

ABT 263 is a high affinity inhibitor of Bcl-2 family proteins (Ki values are 0.5 nM, <1 nM and <1 nM in Bcl-xL, Bcl-2 and Bcl-W respectively). ABT 263 induces G1/G0 phase arrest, apoptosis and autophagy in cancer cells in vitro (IC50 = 3.4 - 12 μM). In vivo, ABT 263 displays a synergistic antitumor effect with rituximab and Bortezomib (Cat. No. 7282), Docetaxel (Cat. No. 4056) and Erlotinib (Cat. No. 7194), and inhibits growth of SCLC xenografts when combined with (+)-JQ1 (Cat. No. 4499). ABT 263 also reduces inflammation and viral-induced senescence in SARS-CoV-2 infection in vivo, and clears senescent cells and rejuvenates aging stem cells. Orally bioavailable.

技术数据 for ABT 263

分子量 974.62
公式 C47H55ClF3N5O6S3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 923564-51-6
PubChem ID 24978538
InChI Key JLYAXFNOILIKPP-KXQOOQHDSA-N
Smiles C(C1=C(CCC(C)(C)C1)C2=CC=C(Cl)C=C2)N3CCN(CC3)C4=CC=C(C(NS(=O)(=O)C5=CC(S(C(F)(F)F)(=O)=O)=C(N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)C=C5)=O)C=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ABT 263

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 97.46 100

制备储备液 for ABT 263

以下数据基于产品分子量 974.62。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.03 mL 5.13 mL 10.26 mL
5 mM 0.21 mL 1.03 mL 2.05 mL
10 mM 0.1 mL 0.51 mL 1.03 mL
50 mM 0.02 mL 0.1 mL 0.21 mL

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参考文献 for ABT 263

参考文献是支持产品生物活性的出版物。

Chen et al (2011) The Bcl-2/Bcl-X(L)/Bcl-w inhibitor, navitoclax, enhances the activity of chemotherapeutic agents in vitro and in vivo. Mol.Cancer Ther. 10 2340 PMID: 21914853

Wang et al (2017) JQ1 synergizes with the Bcl-2 inhibitor ABT-263 against MYCN-amplified small cell lung cancer. Oncotarget 8 86312 PMID: 29156797

Tse et al (2008) ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res. 68 3421 PMID: 18451170

Lee et al (2021) Virus-induced senescence is a driver and therapeutic target in COVID-19. Nature 599 283 PMID: 34517409

Chang et al (2016) Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nat.Med. 22 78 PMID: 26657143

If you know of a relevant reference for ABT 263, please let us know.

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